Having configured a number of Exchange 2007 sites that only use a Single Name SSL certificate a few issues can be experienced. Outlook will often throw a couple errors your way if a few changes aren’t made to Exchange/DNS to ensure they point to the name used in the SSL certificate. These errors are below:

Outlook 2007 Errors:

Information you exchange with this site cannot be viewed or changed by others. However, there is a problem with the site’s security certificate.

Your Out of Office settings cannot be displayed, because the server is currently unavailable. Try again Later.

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If you’re seeing the above I’d suggest checking out the below site on how to best configure Exchange to suit the SSL certificate being used.